abstract：BACKGROUND:Previous studies have revealed inconsistent findings regarding the association of light to moderate alcohol consumption with cardiovascular disease (CVD) and cancer mortality. OBJECTIVES:The aim of this study was to examine the association between alcohol consumption and risk of mortality from all causes, c...

journal_title：Journal of the American College of Cardiology

authors： Xi B,Veeranki SP,Zhao M,Ma C,Yan Y,Mi J

更新日期：2017-08-22 00:00:00

abstract：:In recent times, there has been a considerable increase in the use of aortic bioprostheses (vs. mechanical prostheses) for treating aortic valve disease, and this tendency is likely to continue in the near future. However, the occurrence of structural valve degeneration, limiting valve durability, remains an important...

journal_title：Journal of the American College of Cardiology

authors： Rodriguez-Gabella T,Voisine P,Puri R,Pibarot P,Rodés-Cabau J

更新日期：2017-08-22 00:00:00

abstract：:The noninferiority design is used extensively in current clinical research, but its complex features may hamper the appropriate interpretation of such trials. Thus, understanding the pillars of noninferiority design is indispensable. The authors discuss fundamental concepts regarding the design and interpretation of n...

journal_title：Journal of the American College of Cardiology

authors： Macaya F,Ryan N,Salinas P,Pocock SJ

更新日期：2017-08-15 00:00:00

abstract：OBJECTIVES:To determine, using systematic review of the biomedical literature, whether pacing reduces risk of recurrent syncope and relevant clinical outcomes among adult patients with reflex-mediated syncope. METHODS:MEDLINE (through PubMed), EMBASE, and the Cochrane Central Register of Controlled Trials (through Oct...

journal_title：Journal of the American College of Cardiology

authors： Varosy PD,Chen LY,Miller AL,Noseworthy PA,Slotwiner DJ,Thiruganasambandamoorthy V

更新日期：2017-08-01 00:00:00

abstract：BACKGROUND:Long QT syndrome (LQTS) is a potentially lethal cardiac channelopathy with a 1% to 5% annual risk of LQTS-triggered syncope, aborted cardiac arrest, or sudden cardiac death. OBJECTIVES:This study sought to evaluate LQTS outcomes from a single center in the contemporary era. METHODS:The authors conducted a ...

journal_title：Journal of the American College of Cardiology

authors： Rohatgi RK,Sugrue A,Bos JM,Cannon BC,Asirvatham SJ,Moir C,Owen HJ,Bos KM,Kruisselbrink T,Ackerman MJ

更新日期：2017-07-25 00:00:00

abstract：:The present review synthesizes evidence and discusses issues related to health care quality and equity for women, including minority population subgroups. The principle of "sameness" or women and men receiving equitable, high-quality care is a near-term target, but optimal population health cannot be achieved without ...

journal_title：Journal of the American College of Cardiology

authors： Shaw LJ,Pepine CJ,Xie J,Mehta PK,Morris AA,Dickert NW,Ferdinand KC,Gulati M,Reynolds H,Hayes SN,Itchhaporia D,Mieres JH,Ofili E,Wenger NK,Bairey Merz CN

更新日期：2017-07-18 00:00:00

abstract：BACKGROUND:Detection of subclinical atherosclerosis improves risk prediction beyond cardiovascular risk factors (CVRFs) and risk scores, but quantification of plaque burden may improve it further. Novel 3-dimensional vascular ultrasound (3DVUS) provides accurate volumetric quantification of plaque burden. OBJECTIVES:T...

journal_title：Journal of the American College of Cardiology

authors： López-Melgar B,Fernández-Friera L,Oliva B,García-Ruiz JM,Peñalvo JL,Gómez-Talavera S,Sánchez-González J,Mendiguren JM,Ibáñez B,Fernández-Ortiz A,Sanz J,Fuster V

更新日期：2017-07-18 00:00:00

abstract：:Oxidative stress occurs whenever the release of reactive oxygen species (ROS) exceeds endogenous antioxidant capacity. In this paper, we review the specific role of several cardiovascular risk factors in promoting oxidative stress: diabetes, obesity, smoking, and excessive pollution. Specifically, the risk of developi...

journal_title：Journal of the American College of Cardiology

authors： Niemann B,Rohrbach S,Miller MR,Newby DE,Fuster V,Kovacic JC

更新日期：2017-07-11 00:00:00

abstract：BACKGROUND:Aortic stiffening and reduced nitric oxide (NO) availability may contribute to the pathophysiology of heart failure with preserved ejection fraction (HFpEF). OBJECTIVES:This study compared indices of arterial stiffness at rest and during exercise in subjects with HFpEF and hypertensive control subjects to e...

journal_title：Journal of the American College of Cardiology

authors： Reddy YNV,Andersen MJ,Obokata M,Koepp KE,Kane GC,Melenovsky V,Olson TP,Borlaug BA

更新日期：2017-07-11 00:00:00

abstract：BACKGROUND:Atrial fibrillation (AF) occurs in many clinical contexts and is diagnosed and treated by clinicians across many specialties. This approach has resulted in treatment variations. OBJECTIVES:The goal of this study was to evaluate the association between treating specialty and AF outcomes among patients newly ...

journal_title：Journal of the American College of Cardiology

authors： Perino AC,Fan J,Schmitt SK,Askari M,Kaiser DW,Deshmukh A,Heidenreich PA,Swan C,Narayan SM,Wang PJ,Turakhia MP

更新日期：2017-07-04 00:00:00

abstract：BACKGROUND:The benefit of ideal cardiovascular health (CVH) on health-related outcomes in middle-aged patients is firmly established. In the growing elderly population, the high prevalence of comorbidities and medications for chronic diseases may offset such benefit. OBJECTIVES:This study analyzed the association of i...

journal_title：Journal of the American College of Cardiology

authors： Gaye B,Canonico M,Perier MC,Samieri C,Berr C,Dartigues JF,Tzourio C,Elbaz A,Empana JP

更新日期：2017-06-27 00:00:00

abstract：BACKGROUND:Cardiac allograft vasculopathy (CAV) remains a leading cause of mortality after heart transplantation (HT). Angiotensin-converting enzyme inhibitors (ACEIs) may retard the development of CAV but have not been well studied after HT. OBJECTIVES:This study tested the safety and efficacy of the ACEI ramipril on...

journal_title：Journal of the American College of Cardiology

authors： Fearon WF,Okada K,Kobashigawa JA,Kobayashi Y,Luikart H,Sana S,Daun T,Chmura SA,Sinha S,Cohen G,Honda Y,Pham M,Lewis DB,Bernstein D,Yeung AC,Valantine HA,Khush K

更新日期：2017-06-13 00:00:00

abstract：:Artificial intelligence (AI) is a field of computer science that aims to mimic human thought processes, learning capacity, and knowledge storage. AI techniques have been applied in cardiovascular medicine to explore novel genotypes and phenotypes in existing diseases, improve the quality of patient care, enable cost-e...

journal_title：Journal of the American College of Cardiology

authors： Krittanawong C,Zhang H,Wang Z,Aydar M,Kitai T

更新日期：2017-05-30 00:00:00

abstract：BACKGROUND:Reproductive factors reflective of endogenous sex hormone exposure might have an effect on cardiac remodeling and the development of heart failure (HF). OBJECTIVES:This study examined the association between key reproductive factors and the incidence of HF. METHODS:Women from a cohort of the Women's Health...

journal_title：Journal of the American College of Cardiology

authors： Hall PS,Nah G,Howard BV,Lewis CE,Allison MA,Sarto GE,Waring ME,Jacobson LT,Manson JE,Klein L,Parikh NI

更新日期：2017-05-23 00:00:00

abstract：:More than 1 million heart failure hospitalizations occur annually, and congestion is the predominant cause. Rehospitalizations for recurrent congestion portend poor outcomes independently of age and renal function. Persistent congestion trumps serum creatinine increases in predicting adverse heart failure outcomes. No...

journal_title：Journal of the American College of Cardiology

authors： Costanzo MR,Ronco C,Abraham WT,Agostoni P,Barasch J,Fonarow GC,Gottlieb SS,Jaski BE,Kazory A,Levin AP,Levin HR,Marenzi G,Mullens W,Negoianu D,Redfield MM,Tang WHW,Testani JM,Voors AA

更新日期：2017-05-16 00:00:00

abstract：BACKGROUND:Data conflict regarding the relative effectiveness of carotid artery stenting (CAS) and carotid artery endarterectomy (CEA) for the prevention of stroke due to carotid artery stenosis. OBJECTIVES:The authors performed an updated meta-analysis evaluating the efficacy and safety of CAS versus CEA, given recen...

journal_title：Journal of the American College of Cardiology

authors： Sardar P,Chatterjee S,Aronow HD,Kundu A,Ramchand P,Mukherjee D,Nairooz R,Gray WA,White CJ,Jaff MR,Rosenfield K,Giri J

更新日期：2017-05-09 00:00:00

abstract：:Transcatheter mitral valve repair, particularly edge-to-edge leaflet repair, is a well-established alternative for patients with severe primary mitral regurgitation (MR) considered at high or prohibitive surgical risk. More recently, transcatheter mitral valve replacement (TMVR) has emerged as a potential therapeutic ...

journal_title：Journal of the American College of Cardiology

authors： Regueiro A,Granada JF,Dagenais F,Rodés-Cabau J

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:In patients referred for radiofrequency catheter ablation (RFCA) of ventricular tachycardia (VT) in the setting of structural heart disease, early post-procedural mortality (EM) has not been previously investigated. OBJECTIVES:The purpose of this study was to evaluate EM after catheter ablation of scar-rela...

journal_title：Journal of the American College of Cardiology

authors： Santangeli P,Frankel DS,Tung R,Vaseghi M,Sauer WH,Tzou WS,Mathuria N,Nakahara S,Dickfeldt TM,Lakkireddy D,Bunch TJ,Di Biase L,Natale A,Tholakanahalli V,Tedrow UB,Kumar S,Stevenson WG,Della Bella P,Shivkumar K,Marchl

更新日期：2017-05-02 00:00:00

abstract：BACKGROUND:In the SYNTAX (Synergy Between Percutaneous Coronary Intervention With Taxus and Cardiac Surgery) trial, patients with 3-vessel or left main coronary artery disease (CAD) had improved long-term outcomes with coronary artery bypass graft (CABG) surgery compared with percutaneous coronary intervention (PCI) wi...

journal_title：Journal of the American College of Cardiology

authors： Abdallah MS,Wang K,Magnuson EA,Osnabrugge RL,Kappetein AP,Morice MC,Mohr FA,Serruys PW,Cohen DJ,SYNTAX Trial Investigators.

更新日期：2017-04-25 00:00:00

abstract：BACKGROUND:Mortality in cardiogenic shock (CS) remains high. Early risk stratification is crucial to make adequate treatment decisions. OBJECTIVES:This study sought to develop an easy-to-use, readily available risk prediction score for short-term mortality in patients with CS, derived from the IABP-SHOCK II (Intraaort...

journal_title：Journal of the American College of Cardiology

authors： Pöss J,Köster J,Fuernau G,Eitel I,de Waha S,Ouarrak T,Lassus J,Harjola VP,Zeymer U,Thiele H,Desch S

更新日期：2017-04-18 00:00:00

abstract：BACKGROUND:Despite being widely recognized as the most common form of secondary hypertension, among the general hypertensive population the true prevalence of primary aldosteronism (PA) and its main subtypes, aldosterone-producing adenoma (APA) and bilateral adrenal hyperplasia (BAH), remains a matter of debate. OBJEC...

journal_title：Journal of the American College of Cardiology

authors： Monticone S,Burrello J,Tizzani D,Bertello C,Viola A,Buffolo F,Gabetti L,Mengozzi G,Williams TA,Rabbia F,Veglio F,Mulatero P

更新日期：2017-04-11 00:00:00

abstract：:Installation of automated external defibrillators (AEDs) in schools has been associated with increased survival after sudden cardiac arrest. An authoritative academic research database was interrogated to identify all current state statutes pertaining to AEDs in schools. As of February 2016, 17 of 50 U.S. states (34%)...

journal_title：Journal of the American College of Cardiology

authors： Sherrid MV,Aagaard P,Serrato S,Arabadjian ME,Lium JM,Lium JD,Greenberg HM

更新日期：2017-04-04 00:00:00

abstract：:The Million Hearts Initiative has a goal of preventing 1 million heart attacks and strokes-the leading causes of mortality-through several public health and healthcare strategies by 2017. The American Heart Association and American College of Cardiology support the program. The Cardiovascular Risk Reduction Model was ...

journal_title：Journal of the American College of Cardiology

authors： Lloyd-Jones DM,Huffman MD,Karmali KN,Sanghavi DM,Wright JS,Pelser C,Gulati M,Masoudi FA,Goff DC Jr

更新日期：2017-03-28 00:00:00

abstract：BACKGROUND:Many patients report adverse reactions to, and may not tolerate, statin therapy. These patients may be at increased risk for coronary heart disease (CHD) events and mortality. OBJECTIVES:This study evaluated the risk for recurrent myocardial infarction (MI), CHD events, and all-cause mortality in Medicare b...

journal_title：Journal of the American College of Cardiology

authors： Serban MC,Colantonio LD,Manthripragada AD,Monda KL,Bittner VA,Banach M,Chen L,Huang L,Dent R,Kent ST,Muntner P,Rosenson RS

更新日期：2017-03-21 00:00:00

abstract：BACKGROUND:Among various cardiac autoantibodies (AAbs), those recognizing the β1-adrenergic receptor (β1AR) demonstrate agonist-like effects and induce myocardial damage that can be reversed by β-blockers and immunoglobulin G3 (IgG3) immunoadsorption. OBJECTIVES:The goal of this study was to investigate the role of β1...

journal_title：Journal of the American College of Cardiology

authors： Nagatomo Y,McNamara DM,Alexis JD,Cooper LT,Dec GW,Pauly DF,Sheppard R,Starling RC,Tang WH,IMAC-2 Investigators.

更新日期：2017-02-28 00:00:00

abstract：BACKGROUND:Routine apolipoprotein (apo) measurements for cardiovascular disease (CVD) are restricted to apoA-I and apoB. Here, the authors measured an unprecedented range of apolipoproteins in a prospective, population-based study and relate their plasma levels to risk of CVD. OBJECTIVES:This study sought to measure a...

journal_title：Journal of the American College of Cardiology

authors： Pechlaner R,Tsimikas S,Yin X,Willeit P,Baig F,Santer P,Oberhollenzer F,Egger G,Witztum JL,Alexander VJ,Willeit J,Kiechl S,Mayr M

更新日期：2017-02-21 00:00:00

abstract：BACKGROUND:A limitation of aspirin is that some patients, particularly those with diabetes, may not have an optimal antiplatelet effect. OBJECTIVES:The goal of this study was to determine if oral bioavailability mediates nonresponsiveness. METHODS:The rate and extent of serum thromboxane generation and aspirin pharma...

journal_title：Journal of the American College of Cardiology

authors： Bhatt DL,Grosser T,Dong JF,Logan D,Jeske W,Angiolillo DJ,Frelinger AL 3rd,Lei L,Liang J,Moore JE,Cryer B,Marathi U

更新日期：2017-02-14 00:00:00

abstract：:The American College of Cardiology Adult Congenital and Pediatric Cardiology (ACPC) Section had attempted to create quality metrics (QM) for ambulatory pediatric practice, but limited evidence made the process difficult. The ACPC sought to develop QMs for ambulatory pediatric cardiology practice. Five areas of interes...

journal_title：Journal of the American College of Cardiology

authors： Chowdhury D,Gurvitz M,Marelli A,Anderson J,Baker-Smith C,Diab KA,Edwards TC,Hougen T,Jedeikin R,Johnson JN,Karpawich P,Lai W,Lu JC,Mitchell S,Newburger JW,Penny DJ,Portman MA,Satou G,Teitel D,Villafane J,Williams

更新日期：2017-02-07 00:00:00

abstract：BACKGROUND:Heart failure (HF) is a complex syndrome associated with a maladaptive innate immune system response that leads to deleterious cardiac remodeling. However, the underlying mechanisms of this syndrome are poorly understood. Nucleotide-binding oligomerization domain-containing protein 1 (NOD1) is a newly recogn...

journal_title：Journal of the American College of Cardiology

authors： Val-Blasco A,Piedras MJGM,Ruiz-Hurtado G,Suarez N,Prieto P,Gonzalez-Ramos S,Gómez-Hurtado N,Delgado C,Pereira L,Benito G,Zaragoza C,Domenech N,Crespo-Leiro MG,Vasquez-Echeverri D,Nuñez G,Lopez-Collazo E,Boscá L,Fernánde

更新日期：2017-01-31 00:00:00

abstract：:In the second part of this 2-part series on pacemakers, we present recent advances in pacemakers and preview future developments. Cardiac resynchronization therapy (CRT) is a potent treatment for heart failure in the setting of ventricular dyssynchrony. Successful CRT using coronary venous pacing depends on appropriat...

journal_title：Journal of the American College of Cardiology

authors： Madhavan M,Mulpuru SK,McLeod CJ,Cha YM,Friedman PA

更新日期：2017-01-17 00:00:00

abstract：BACKGROUND:Clinical practice guidelines recommend post-operative dual antiplatelet therapy (DAPT) in patients who undergo coronary artery bypass grafting (CABG) following acute coronary syndromes (ACS). OBJECTIVES:The authors have evaluated DAPT utilization rates and associated outcomes among post-CABG patients with d...

journal_title：Journal of the American College of Cardiology

authors： van Diepen S,Fuster V,Verma S,Hamza TH,Siami FS,Goodman SG,Farkouh ME

更新日期：2017-01-17 00:00:00

abstract：BACKGROUND:Angiotensin-(1-9) [Ang-(1-9)] is a novel peptide of the counter-regulatory axis of the renin-angiotensin-aldosterone system previously demonstrated to have therapeutic potential in hypertensive cardiomyopathy when administered via osmotic mini-pump. Here, we investigate whether gene transfer of Ang-(1-9) is ...

journal_title：Journal of the American College of Cardiology

authors： Fattah C,Nather K,McCarroll CS,Hortigon-Vinagre MP,Zamora V,Flores-Munoz M,McArthur L,Zentilin L,Giacca M,Touyz RM,Smith GL,Loughrey CM,Nicklin SA

更新日期：2016-12-20 00:00:00

abstract：:Ischemic heart disease is a complex disease process caused by the development of coronary atherosclerosis, with downstream effects on the left ventricular myocardium. It is characterized by a long preclinical phase, abrupt development of myocardial infarction, and more chronic disease states such as stable angina and ...

journal_title：Journal of the American College of Cardiology

authors： Dweck MR,Williams MC,Moss AJ,Newby DE,Fayad ZA

更新日期：2016-11-15 00:00:00

abstract：:Therapeutic fibrinolysis has been dominated by the experience with tissue-type plasminogen activator (t-PA), which proved little better than streptokinase in acute myocardial infarction. In contrast, endogenous fibrinolysis, using one-thousandth of the t-PA concentration, is regularly lysing fibrin and induced Thrombo...

journal_title：Journal of the American College of Cardiology

authors： Gurewich V

更新日期：2016-11-08 00:00:00

abstract：BACKGROUND:The optimal systolic blood pressure (SBP) treatment goal is in question, with SPRINT (Systolic Blood Pressure Intervention Trial) suggesting benefit for 120 mm Hg. However, achieving an SBP this low may reduce diastolic blood pressure (DBP) to levels that could compromise myocardial perfusion. OBJECTIVES:Th...

journal_title：Journal of the American College of Cardiology

authors： McEvoy JW,Chen Y,Rawlings A,Hoogeveen RC,Ballantyne CM,Blumenthal RS,Coresh J,Selvin E

更新日期：2016-10-18 00:00:00

abstract：BACKGROUND:Small-scale studies focused mainly on nonischemic cardiomyopathy (NICM) have shown that a subset of left ventricular assist device (LVAD) patients can achieve significant improvement of their native heart function, but the impact of ischemic cardiomyopathy (ICM) has not been specifically investigated. Many p...

journal_title：Journal of the American College of Cardiology

authors： Wever-Pinzon J,Selzman CH,Stoddard G,Wever-Pinzon O,Catino A,Kfoury AG,Diakos NA,Reid BB,McKellar S,Bonios M,Koliopoulou A,Budge D,Kelkhoff A,Stehlik J,Fang JC,Drakos SG

更新日期：2016-10-18 00:00:00

abstract：BACKGROUND:Carbamylation alters low-density lipoprotein (LDL) structure and is thought to promote vascular inflammation and dysfunction in patients with chronic kidney disease (CKD). OBJECTIVES:This study sought to determine whether carbamylated LDL (cLDL) exerts prothrombotic effects in vascular cells and platelets a...

journal_title：Journal of the American College of Cardiology

authors： Holy EW,Akhmedov A,Speer T,Camici GG,Zewinger S,Bonetti N,Beer JH,Lüscher TF,Tanner FC

更新日期：2016-10-11 00:00:00

abstract：:Disorders of potassium homeostasis can potentiate the already elevated risk of arrhythmia in heart failure. Heart failure patients have a high prevalence of chronic kidney disease, which further heightens the risk of hyperkalemia, especially when renin-angiotensin-aldosterone system inhibitors are used. Acute treatmen...

journal_title：Journal of the American College of Cardiology

authors： Sarwar CM,Papadimitriou L,Pitt B,Piña I,Zannad F,Anker SD,Gheorghiade M,Butler J

更新日期：2016-10-04 00:00:00

abstract：BACKGROUND:Incidence and outcome of mitral valve (MV) surgery are unknown in patients with hypertrophic obstructive cardiomyopathy (HOCM) undergoing extended transaortic septal myectomy. OBJECTIVES:This study sought to define indications and suitable operative strategy for mitral regurgitation (MR) in patients with HO...

journal_title：Journal of the American College of Cardiology

authors： Hong JH,Schaff HV,Nishimura RA,Abel MD,Dearani JA,Li Z,Ommen SR

更新日期：2016-10-04 00:00:00

abstract：BACKGROUND:It is unclear whether the non-vitamin K antagonist oral anticoagulant agents rivaroxaban and dabigatran are superior to warfarin for efficacy and safety outcomes in Asians with nonvalvular atrial fibrillation (NVAF). OBJECTIVES:The aim of this study was to compare the risk for thromboembolic events, bleedin...

journal_title：Journal of the American College of Cardiology

authors： Chan YH,Kuo CT,Yeh YH,Chang SH,Wu LS,Lee HF,Tu HT,See LC

更新日期：2016-09-27 00:00:00